William T. Doerrler
Associate Professor
BMB Division
PhD: University of Texas Southwestern Medical Center, 1999
Phone: 225-578-7904
Cell: 225-810-8390
Lab Phone: 225-578-7903
Office: 508 Life Sciences Building
Lab: 508/510 Life Sciences Building
E-mail: wdoerr@lsu.edu
Area of Interest
Bacterial resistance to biocides and antibiotics is an increasing problem. Often, antibiotic resistance is conferred by expression of membrane-embedded efflux pumps that can accommodate numerous unrelated drugs. We study a family of membrane transporters required for antibiotic resistance in numerous bacterial species. This family is called the DedA/Tvp38 family in public databases based upon similarity to E. coli DedA and yeast Golgi apparatus membrane protein/SNARE Associated Protein Tvp38. Currently, there are thousands of DedA family genes in the online protein database and they are present in most genomes, including that of humans. We have shown that members of the DedA family are required for cell division and drug resistance in E. coli and for resistance to the last resort antibiotic colistin in species of Burkholderia and Klebsiella. Future studies are aimed at characterizing these and other members of the conserved and widespread DedA family.
Selected Publications
Vijay Tiwari, Amit Sharma, Reygan Braga, Emily Garcia, Ridhwana Appiah, Renee Fleeman, Basel H. Abuaita, Marianna Patrauchan and William T. Doerrler. . Microbiology Spectrum 2024 Feb 6;12(2):e0380723. doi: 10.1128/spectrum.03807-23
Asif Iqbal, George Nwokocha, Vijay Tiwari, Inderjit K. Barphagha, Anne Grove, Jong Hyun Ham, William T. Doerrler. . Molecular Plant Pathology; 2023 July 10.
Molecular Plant Pathology Highlight blog-
Tiwari V, Panta PR, Billiot CE, Douglass MV, Herrera CM, Trent MS, and William T. Doerrler. Scientific Reports; 2021 Dec 21;11(1):24365. doi: 10.1038/s41598-021-03834-3.
Iqbal A, Panta PR, Ontoy J, Bruno J, Ham JH and William T. Doerrler. Applied and Environmental Microbiology. 2021 Aug 26;87(18):e0091521.
Panta PR and Doerrler WT. Scientific Reports; 2021 Jun 24;11(1):13230.
Panta PR and Doerrler WT. Frontiers in Microbiology, 12 January, 2021.
Pradip R. Panta, Sujeet Kumar, Caroline F. Stafford, Caitlin E. Billiot, Martin V. Douglass, Carmen M. Herrera, M. Stephen Trent, and William T. Doerrler, Frontiers in Microbiology, 05 Nov 2019
Kumar S, Tiwari V, Doerrler WT. FEMS Microbiology Letters 364 (12) 2017.
Jana B, Cain AK, Doerrler WT, Boinett CJ, Fookes MC, Parkhill J, Guardabassi L. TScientific Reports 7; 42483, 2017.
Kumar S, Bradley CL, Mukashyaka P and Doerrler WT. FEMS Microbiology Letters 363 (13), 2016.
Kumar S and Doerrler WT. J Bacteriology 197, 2292-2300, 2015.
Kumar S and Doerrler WT. Antimicrobial Agents and Chemotherapy 58, 923-930, 2014.
Doerrler WT, Sikdar R, Kumar S and Boughner LA. . J Bacteriology 195; 3-11, 2013.
Sikdar R, Simmons AR, and Doerrler WT. J Bacteriology 195; 12-24, 2013.